"This would offer a third class of anti-retroviral medications that can be combined with reverse transcriptase inhibitors and protease inhibitors. And since it is a new mechanism of action, these compounds are active against multi-drug resistant variants. So variants that are resistant to all current therapies have been selected in HIV-patients," she said.
Current anti-AIDS drugs eventually become resistant to therapy, or stop working, because the virus changes its shape.
While researchers are encouraged by the success with the compound's effectiveness in monkey trials, developing a drug that is equally effective in humans can be difficult.
Steven Young is executive director of the Department of Medicinal Chemistry at Merck. He says, if scientists find a compound that is equally effective in people, the company would ask U.S. regulators to speed approval of the drug.
"Yeah, I really think that's what we're hoping for," he said. "I mean, we need to get data that show it has robust anti-viral effects in people. And if we're able to get that data, I think we would petition for fast track status."
Dr. Young says an integrase inhibitor has the potential to prevent drug resistance.
"To ensure our best chance of preventing resistance, we would give this as part of a cocktail therapy," he added. "And I think it's really our plan that we would test this with reverse transcriptase inhibitors and protease inhibitors, as well."
47. If the drug proves effective in human trials, it could enhance the effectiveness of existing AIDS drugs in ________.
48. What has become standard cocktail therapy?
49. While integrase deletes an immune cell's genetic material and replaces it with its own, it acts like ________ in a word processor.
50. Why would anti-AIDS drugs stop working?
51. According to Steven Young, if scientists get the data that ________, they would petition for fast track status.
Section B
Directions: There are 2 passages in this section. Each passage is followed by some questions or unfinished statements. For each of them there are four choices marked [A], [B], [C] and [D]. You should decide on the best choice and mark the corresponding letter on Answer Sheet 2 with a single line through the center.
Passage One
Questions 52 to 56 are based on the following passage.
Occasional self-medication has always been part of normal living. The making and selling of drugs have a long history and are closely linked, like medical practice itself, with the belief in magic. Only during the last hundred years or so has the development of scientific techniques made it possible for some of the causes of symptoms to be understood, so that more accurate diagnosis has become possible. The doctor is now able to follow up the correct diagnosis of many illnesses with specific treatment of their causes. In many other illnesses, of which the causes remain unknown, it is still limited, like the unqualified prescriber, to the treatment of symptoms. The doctor is trained to decide when to treat symptoms only and when to attack the cause: this is the essential difference between medical prescribing and self-medication.
The advance of technology has brought about much progress in some fields of medicine, including the development of scientific drug therapy. In many countries public health organization is improving and people's nutritional standards have risen. Parallel with such beneficial trends have two adverse effects. One is the use of high-pressure advertising by the pharmaceutical industry, which has tended to influence both patients and doctors and has led to the overuse of drugs generally. The other is the emergence of the sedentary society with its faulty ways of life: lack of exercise, over-eating, unsuitable eating, insufficient sleep, excessive smoking and drinking. People with disorders arising from faulty habits such as these, as well as from unhappy human relationships, often resort to self-medication and so add the taking of pharmaceuticals to the list. Advertisers go to great lengths to catch this market.
Clever advertising, aimed at chronic sufferers who will try anything because doctors have not been able to cure them, can induce such faith in a preparation, particularly if steeply priced, that it will produce—by suggestion—a very real effect in some people. Advertisements are also aimed at people suffering from mild complaints such as simple colds and coughs, which clear up by themselves within a short time.
These are the main reasons why laxatives, indigestion remedies, painkillers, tonics, vitamin and iron tablets and many other preparations are found in quantity in many households. It is doubtful whether taking these things ever improves a person's health; it may even make it worse. Worse because the preparation may contain unsuitable ingredients; worse because the taker may become dependent on them; worse because they might be taken in excess; worse because they may cause poisoning, and worse of all because symptoms of some serious underlying cause may be masked and therefore medical help may not be sought.
52. The first paragraph is intended to ________.
[A] suggest that self-medication has a long history
[B] define what diagnosis means exactly
[C] praise doctors for their expertise
[D] tell the symptoms from the causes
53. Advertisements are aimed at people suffering from mild complaints because ________.
[A] they often watch ads on TV
[B] they are more likely to buy the drugs advertised
[C] they generally lead a sedentary life
[D] they don't take to sports and easily catch colds
54. Paragraphs 2 and 3 explain ________.
[A] those good things are not without side effects
[B] why clever advertising is so powerful
[C] why in modern times self-medication is still practised
[D] why people develop faulty ways of life
55. The author tells us in paragraph 4 ________.
[A] the reasons for keeping medicines at home
[B] people's doubt about taking drugs
[C] what kind of medicine people should prepare at home
[D] the possible harms self-medication may do to people
56. The best title for the passage would be ________.
[A] Medical Practice [B] Clever Advertising
[C] Self-Medication [D] Self-Treatment
Passage Two
Questions 57 to 61 are based on the following passage.
The age of gilded youth is over. Today's under-thirties are the first generation for a century who can expect a lower living standard than their parents.
Research into the lifestyles and prospects of people who were born since 1970 shows that they are likely to face a lifetime of longer working hours, lower job security and higher taxes than the previous generation.
When they leave work late in the evening, they will be more likely to return to a small rented flat than to a house of their own. When, eventually, they retire, their pensions are far lower in real terms than those of their immediate forebears.
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