近5年主持的科研项目：

　　1) B[a]P/B[a]PDE致肺癌发生新机制---抑制PHLPP2表达的发现与分子机制研究、浙江省自然科学基金重点项目(LZ14H260001)、30万、2014.01-2017.12.

　　2) DGKα和ζ协同调控T 细胞无能和调节性T 细胞功能的分子机制、国家自然科学基金面上项目(31270958)、80万、2013.01-2016.12.

　　3) 砷暴露下p50调控细胞凋亡的分子机制研究、国家自然科学海外及港澳学者合作研究基金(81229002)、200万、2013.01-2016.12. (中方负责人)

　　4) GM-CSF/TNFa膜表面双重修饰的前列腺癌治疗性疫苗、863计划重大项目“疫苗研发关键技术与产品研发”分题(2012AA02A407)、306万、2012.01-2015.12.

　　5) 可溶性肿瘤坏死因子受体II-脂联素球部融合蛋白的开发研究、卫生部科研基金(201231029)、30万、2012.06-2015.06.

　　6) 连接B[a]P/B[a]PDE诱导的肺慢性炎症微环境至肺癌发生发展的分子机制、国家自然科学基金重大研究计划培育项目(91029706)、60万、2011.01-2013.12.

　　7) JNK1经VHL-非依赖途径调节HIF-1α蛋白降解的新功能及其机制研究、国家自然科学基金面上项目(30971516)、30万、2010.01-2012.12.

　　8) IKK/NFκBp50/GADD45α凋亡通路的分子基础、国家自然科学基金海外及港澳学者合作基金(30928023)、20万、2010.01-2011.12. (中方负责人)

　　9) 可溶性肿瘤坏死因子受体II-脂联素球部融合蛋白的开发研究、国家“重大新药创制”科技重大专项项目(2009ZX09103-649)、150万、2009.01-2010.12.

　　10) GM-CSF/TNFα膜表面双重修饰的前列腺癌治疗性疫苗的研制、浙江省重大科技专项(2008C14082)、100万、2009.01-2011.12.

　　11) 浙江省自然科学基金杰出青年团队(R2080407)、51万、2009.01-2011.12.

　　12) 浙江省卫生高层次创新人才培养工程、80万、2008.07-2013.06.

　　13) 蛋白质锚定技术平台的开发研究(2008R10031)、浙江省钱江人才计划、10万、2008.01-2010.12.

　　14) 蛋白质锚定技术用于表浅膀胱癌术后复发的防治， 863计划课题(2006AA02Z4C4)、260 万元、2006.12-2008.12.

　　发表的代表性论文：(*通讯作者)

　　1. Zhang D, Liang Y, Xie Q, Gao G, Wei J, Huang H, Li J, Gao J, Huang C*. A novel post-translational modification of nucleolin, SUMOylation at K294, mediates arsenite-induced cell death by regulating gadd45a mRNA stability. J Biol Chem. 2015 Jan 5. [Epub ahead of print]

　　2. Lin M, Wang J, Zhou G, Wang J, Wu N, Lu J, Gao J, Chen X, Shi J, Zuo X*, Fan C*.Programmable engineering of a biosensing interface with tetrahedral DNA nanostructures for ultrasensitive DNA detection. Angew Chem Int Ed Engl. 2014 Dec 29. [Epub ahead of print]

　　3. Jin H, Yu Y, Hu Y, Lu C, Li J, Gu J, Zhang L, Huang H, Zhang D, Wu X, Gao J*, Huang C*. Divergent behaviors and underlying mechanisms of cell migration and invasion in non-metastatic T24 and its metastatic derivative T24T bladder cancer cell lines. Oncotarget. 2014 Nov. 5 [Epub ahead of print]。

　　4. Wang J, Lu J, Su S, Gao J*, Huang Q, Wang L, Huang W, Zuo X*. Binding-induced collapse of DNA nano-assembly for naked-eye detection of ATP with plasmonic gold nanoparticles. Biosens Bioelectron. 2014 Oct. 18 [Epub ahead of print]. (影响因子6.451)

　　5. Xiang D, Zhang H, Bai J, Ma J, Li M, Gao J, Wang C. Clinical application of neutrophil gelatinase-associated lipocalin in the revised chronic kidney disease classification. Int J Clin Exp Pathol. 2014;7(10)：7172-81.

　　6. Cai Q, Zhao A, Yin Y, Ma L, Jiao Z, Zhi H, Lai S, Cheng S, Yang H, Lu Y*, Siminovitch K*, Gao J*. Efficient production of sTNFRII-gAD fusion protein in large quantity by use of the modified CHO-S cell expression system. PloS One 2014;9(10)：e111229. (影响因子3.534)

　　7. Wu W, Li J, Pan D, Li J, Song S, Rong M, Li Z, Gao J, Lu J. Gold nanoparticle-based enzyme-linked antibody-aptamer sandwich assay for detection of Salmonella Typhimurium. ACS Appl Mater Interfaces. 2014; 6(19)：16974-81.

　　8. Lan J, Yang K, Byrd D, Hu N, Amet T, Shepherd N, Desai M, Gao J, Gupta S, Sun Y, Yu Q. Provirus activation plus CD59 blockage triggers antibody-dependent complement-mediated lysis of latently HIV-1-infected cells. J Immunol. 2014; 192(6)：2643-50.

　　9. Wei J, Du K, Cai Q, Ma L, Jiao Z, Tan J, Xu Z, Li J, Luo W, Chen J, Gao J*, Zhang D*, Huang C*. Lead induces COX-2 expression in glial cells in a NFAT-dependent, AP-1/NFκB-independent manner. Toxicology. 2014;325:67-73.

　　10. Chen X, Zhou G, Song P, Wang J, Gao J, Lu J, Fan C, Zuo X. Ultrasensitive electrochemical detection of prostate-specific antigen by using antibodies anchored on a DNA nanostructural scaffold. Anal Chem. 2014;86(15)：7337-42.

　　11. Wang Y, Zhao W, Zhang L, Zhao YN, Li F, Zhang Z, Dai YD, Li WF, Qiao Y, Chen C, Gao J*, Zhu M*. Molecular and cellular basis of the regulation of lymphatic contractility and lymphatic absorption. Int J Biochem Cell Biol. 2014; 53:134-40.(影响因子4.24)

　　12. Qiao Y, He W, Chen C, Zhang C, Zhao W, Wang P, Zhang L, Wu Y, Yang X, Peng Y, Gao J, Kamm K, Stull J, Zhu M. Myosin Phosphatase Target Subunit 1 (MYPT1) Regulates the Contraction and Relaxation of Vascular Smooth Muscle and Maintains Blood Pressure. J Biol Chem. 2014;289(32)：22512-23.

　　13. Wu J, Shin J, Xie D, Wang H, Gao J, Zhong XP. Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity. J Immunol. 2014;192(6)：2643-50.

　　14. Shin J, Wang S, Deng W, Wu J, Gao J*, Zhong XP*. Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function. Proc Natl Acad Sci USA. 2014; 111(8)：E776-83. (影响因子9.737)

　　15. Yu Y, Zhang D, Huang H, Li J, Zhang M, Wan Y, Gao J, Huang C. NF-kB1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1.Oncogene 2014; 33:996-1005.

　　16. Sun Q, Teong B, Chen IF, Chang SJ, Gao J, Kuo SM. Enhanced apoptotic effects of dihydroartemisinin-aggregated gelatin and hyaluronan nanoparticles on human lung cancer cells. J Biomed Mater Res B Appl Biomater. 2014; 102(3)：455-62.

　　17. Huang H, Ma L, Li J, Yu Y, Zhang D, Wei J, Jin H, Xu D, Gao J*, Huang C*. NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression. Oncotarget 2014; 5:493-505. (影响因子6.636)

　　18. Wan Y, Wang P, Su Y, Zhu X, Yang S, Lu J, Gao J, Fan C, Huang Q. Ultrasensitive electrochemical DNA sensor based on the target induced structural switching and surface-initiated enzymatic polymerization. Biosens Bioelectron. 2014;55:231-6.

　　19. Deng X, Yang H, He X, Liao Y, Zheng C, Zhou Q, Zhu C, Zhang G, Gao J, Zhou N. Activation of Bombyx neuropeptide G protein-coupled receptor A4 via a Gαi-dependent signaling pathway by direct interaction with neuropeptide F from silkworm, Bombyx mori. Insect Biochem Mol Biol. 2014;45:77-88.

　　20. Wu J, Zhang XJ, Shi KQ, Chen YP, Ren YF, Song YJ, Li G, Xue YF, Fang YX, Deng ZJ, Xu X, Gao J, Tang KF. Hepatitis B surface antigen (HBsAg) inhibits MICA and MICB expression via induction of cellular miRNAs in hepatocellular carcinoma cells. Carcinogenesis. 2014; 35(1)：155-63.(影响因子5.635)

　　21. Chang C, Zhao W, Xie B, Deng Y, Han T, Cui Y, Dai Y, Zhang Z, Gao J*, Guo H*, Yan J*. Pao Pereira extract suppresses castration-resistant prostate cancer cell growth, survival, and invasion through inhibition of NFκB signaling. Integr Cancer Ther 2013; 13(3)：249-258.(影响因子2.354)

　　22. Tong Y, Li F, Lu Y, Cao Y, Gao J*, Liu J*. Rapamycin-sensitive mTORC1 signaling is involved in physiological primordial follicle activation in mouse ovary. Mol Reprod Dev 2013;80(12)：1018-34. (影响因子2.812)

　　23. Qin K, Ding T, Xiao Y, Ma W, Wang Z, Gao J, Zhao L. Differential responses of neuronal and spermatogenic cells to the doppel cytotoxicity. PLoS One 2013;8(12)：e82130.

　　24. Li X, Xu X, Jin A, Jia Q, Zhou H, Kang S, Lou Y, Gao J*, Lu J*. Self-assembled HCV core virus-like particles targeted and inhibited tumor cell migration and invasion. Nanoscale Res Lett 2013 Sep 27;8(1)：401. (影响因子2.542)

　　25. Du K, Yu Y, Zhang D, Luo W, Huang H, Chen J, Gao J, Huang C. NFκB1 (p50) suppresses SOD2 expression via inhibiting FoxO3a transactivation in a miR190/PHLPP1/Akt-dependent axis. Mol Biol Cell. 2013;24(22)：3577-83. (影响因子4.604)

　　26. Xiang D, Zhang H, Bai J, Ma J, Li M, Gao W, Zhang X, Gao J*, Wang C*. Particle-enhanced turbidimetric immunoassay for determination of serum neutrophil gelatinase-associated lipocalin on the Roche Cobas c501 analyzer. Clin Biochem. 2013;46(16-17)：1756-60 2013. (影响因子2.45)

　　27. Yu Y, Huang H, Li J, Zhang J, Gao J, Lu B, Huang C. GADD45β mediates p53 protein degradation via Src/PP2A/MDM2 pathway upon arsenite treatment. Cell Death Dis. 2013;4:e637. (影响因子6.044)

　　28. Bianying F, Linjie G, Lihua W, Fan L, Jianxin L, J Gao, Chunhai F, Qing H. A graphene oxide-based fluorescent biosensor for the analysis of Peptide-receptor interactions and imaging in somatostatin receptor subtype 2 overexpressed tumor cells. Anal Chem. 2013;85(16)：7732-7.

　　29. Y Li, L Du*, H Qiu, G Zhao, L Wang, Y Zhou, S Jiang, J Gao*. A recombinant protein containing highly conserved hemagglutinin residues 81–122 of influenza H5N1 induces strong humoral and mucosal immune responses. BioScience Trends.2013;7(3)：129-37. (影响因子1.582)

　　30. Zhao YN, Li WF, Li F, Zhang Z, Dai YD, Xu AL, Qi C, Gao J*, Gao J*. Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway. Biochem Biophys Res Commun. 2013; 435(4)：597-602. (影响因子2.406)

　　31. Zhu JJ, Xu YQ, He JH, Yu HP, Huang CJ, Gao J, Dong QX, Xuan YX, Li CQ. Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish. J Appl Toxicol. 2013; 67(1)：25-32. (影响因子2.150)

　　32. He JH, Guo SY, Zhu F, Zhu JJ, Chen YX, Huang CJ, Gao J, Dong QX, Xuan YX, Li CQ. A zebrafish phenotypic assay for assessing drug-induced hepatotoxicity. J Pharmacol Toxicol Methods 2013; 67(1)：25-32.

　　33. Shi X, Zhang X, Li J, Guo F, Hu Z, Jing Y, Bai L, Chen S, Wan P, Wang F, Gao J, Tan W. Sequential administration of GM-CSF and IL-2 surface-modified MB49 cells vaccines against the metastatic bladder cancer. Urol Oncol 2013;31(6)：883-93. (影响因子3.216)

　　34. Cao Z, Zhang R, Li J, Huang H, Zhang D, Zhang J, Gao J*, Chen J*, Huang C*. X-linked inhibitor of apoptosis protein (XIAP) regulation of cyclin D1 protein expression and cancer cell anchorage-independent growth via its E3 ligase-mediated protein phosphatase 2A/c-Jun axis. J Biol Chem. 2013; 288(28)：20238-47.(影响因子4.651)

　　35. Che X, Liu J, Huang H, Mi X, Xia Q, Li J, Zhang D, Ke Q*, Gao J*, Huang C*. p27 Suppresses cyclooxygenase-2 expression by inhibiting p38β and p38δ-mediated CREB phosphorylation upon arsenite exposure. Biochim Biophys Acta - Mol Cell Res. 2013; 1832(9)： 2083-91. (影响因子4.808)

　　36. Yu Y, Li J, Wan Y, Lu J, Gao J*, Huang C*. GADD45α induction by nickel negatively regulates JNKs/p38 activation via promoting PP2Cα expression. PLoS One 2013; 8(3)：e57185. (影响因子4.092)

　　37. Fan Li, Hao Pei, Lihua Wang*, Jianxin Lu, Jimin Gao*, Bowei Jiang, Xingchun Zhao, Chunhai Fan*. Nanomaterial-based fluorescent DNA analysis: A comparative study of the quenching effects of graphene oxide, carbon nanotubes, and gold nanoparticles. Adv. Funct. Mater. 2013; 23(33)：4140–4148.(影响因子9.765)

　　38. Mao X, Wei M, Zhu C, Lu J, Gao J*, Simon A, Chen N, Shi J, Huang Q, Fan C*. Real time in vitro regulation of DNA methylation using a 5-fluorouracil conjugated DNA-based stimuli-responsive platform. ACS Appl Mater Interfaces. 2013; 5(7)：2604-9.(影响因子5.008)

　　39. Shi H, Zhang Y, Zhang G, Guo J, Zhang X, Song H, Lv J, Gao J*, Wang Y, Chen L*, Wang Y*. Systematic functional comparative analysis of four single-stranded DNA-binding proteins and their affection on viral RNA metabolism. PLoS One 2013; 8(1)： e55076. (影响因子4.092)

　　40. Cao Q, Zhang X, Lu L, Yang L, Gao J, Gao Y, Ma H, Cao Y. Klf4 is required for germ-layer differentiation and body axis patterning during Xenopus embryogenesis. Development. 2012;139(21)：3950-61.

　　41. Du L, Li Y, Gao J, Zhou Y, Jiang S. Potential strategies and biosafety protocols used for dual-use research on highly pathogenic influenza viruses. Rev Med Virol. 2012;22(6)：412-9.

　　42. Su S, Wu W, Gao J*, Lu J, Fan C*. Nanomaterials-based sensors for applications in environmental monitoring. J Mater Chem 2012; 22:18101-18110. (影响因子6.101)

　　43. Pei H, Li J, Lv M, Wang J, Gao J, Lu J, Li Y, Huang Q, Hu J, Fan C. A graphene-based sensor array for high-precision and adaptive target identification with ensemble aptamers. J Am Chem Soc. 2012; 134(33)：13843-9. (影响因子10.677)

　　44. Krishna S, Xie D, Gorentla B, Shin J, Gao J, Zhong XP. Chronic activation of the kinase IKKβ impairs T cell function and survival. J Immunol 2012 ;189(3)：1209-19. (影响因子5.745)

　　45. Zhang D, Li J, Zhang M, Gao G, Zuo Z, Yu Y, Zhu L, Gao J, Huang C. The Requirement of c-Jun N-terminal Kinase 2 in Regulation of Hypoxia-inducing Factor-1α mRNA Stability. J Biol Chem. 2012; 287(41)：34361-71. (影响因子5.328)

　　46. Luo M, Liu D, Zhang L, Huang S, Yang W, Zhang L, Cui T, Ma H, Wang Z, Sun Q, Xiong C, Zhu J, Li J, Wu X, Jin L, Hu Z, Gao J*. Protective effects of a novel trimerized sTNFRII on acute liver injury. Int Immunopharmacol. 2012;13:88-92. (影响因子2.325)

　　47. Bai L, Hu Z, Wang F, Xu X, Xia C, Jin L, Li J, Gao J*. Generation of streptavidin-tagged human-granulocyte macrophage colony-stimulating factor fusion proteins.Nan Fang Yi Ke Da Xue Xue Bao. 2012;32:1389-93.

　　48. Zhang X, Shi X, Li J, Hu Z, Zhou D, Gao J*, Tan W*. A Novel Therapeutic Vaccine of Mouse GM-CSF Surface Modified MB49 Cells Against Metastatic Bladder Cancer. J Urol 2012; 87:1071-9.(影响因子3.746)

　　49. Chen Y, Shen S, Gorentla BK, Gao J*, Zhong XP*. Murine regulatory T cells contain hyperproliferative and death-Prone subsets with differential ICOS expression. J Immunol 2012; 188:1698-707. (影响因子5.745)

　　50. Shi Y, Huang H, Deng X, He X, Yang J, Yang H, Shi L, Mei L, Gao J*, Zhou N*. Identification and Functional Characterization of Two Orphan G-protein-coupled Receptors for Adipokinetic Hormones from Silkworm Bombyx mori. J Biol Chem 2011; 286(49)：42390-402. (影响因子5.328)

　　51. Zhang X, Shi X, Li J, Hu Z, Guo F, Huang X, Zhang Z, Sun P, Jing Y, Gao J, Tan W. Novel immunotherapy for metastatic bladder cancer using vaccine of human interleukin-2 surface-modified MB 49 cells. Urology 2011;78:722.e1-6. (影响因子2.334)

　　52. Liu G, Chen H, Peng H, Song S, Gao J, Lu J, Ding M, Li L, Ren S, Zou Z, Fan C. A carbon nanotube-based high-sensitivity electrochemical immunosensor for rapid and portable detection of clenbuterol. Biosens Bioelectron 2011; 28:308-13. (影响因子5.437)

　　53. Huang H, Deng X, He X, Yang W, Li G, Shi Y, Shi L, Mei L, Gao J, Zhou N*. Identification of distinct c-terminal domains of the Bombyx adipokinetic hormone receptor that are essential for receptor export, phosphorylation and internalization. Cell Signal 2011; 23:1455-65.

　　54. He Q, Li J, Yin W, Song Z, Zhang Z, Yi T, Tang J, Wu D, Lu Y, Wang Z, Liu D, Zhang X, Hu Z, Gao J*. Low-dose paclitaxel enhances the anti-tumor efficacy of GM-CSF-surface-modified whole-tumor-cell vaccine in mouse model of prostate cancer. Cancer Immunol Immunother 2011;60:715-30.(影响因子3.701)

　　55. Zhang Z, Xu X, Zhang X, Chen X, Chen Q, Dong L, Hu Z, Li J, Gao J*.The therapeutic potential of SA-sCD40L in the orthotopic model of superficial bladder cancer. Acta Oncologica 2011;50:1111-8.(影响因子3.330)

　　56. Chen Y, Nie X, Cui X, Wu W, Zhang J, Wen C, Gao J*, Jinxin Lu*. Direct Colorimetric Biosensors from Polydiacetylenes. Curr Org Chem 2011;15: 518-533.(影响因子2.920)

　　57. Zhang F, Wu J, Xu C, Lin X, Zhao H, Lu J, Zhang Y, Lu J, Zhang X, Ma J, Shu Y, Lou Y, Gao J*, Wang Y*. Infectivity of pseudotyped particles pairing hemagglutinin of highly pathogenic avian influenza a H5N1 virus with neuraminidases of the 2009 pandemic H1N1 and a seasonal H3N2. J Bioterr Biodef 2011; 2:1-6.

　　58. Wen B, Deng Y, Guan J, Yan W, Wang Y, Tan W, Gao J*. Signal peptide replacements enhance expression and secretion of hepatitis C virus envelope glycoproteins. Acta Biochim Biophys Sin (Shanghai). 2011 ;43:96-102.(影响因子1.547)

　　59. Wu W, Hu H, Li F, Wang L, Gao J, Lu J, Fan C. A graphene oxide-based nano-beacon for DNA phosphorylation analysis. Chem Commun (Camb).2010;47:1201-3.(影响因子5.504)

　　60. Wu J, Zhang F, Wang M, Xu C, Song J, Zhou J, Lin X, Zhang Y, Wu X, Tan W, Lu J, Zhao H, Gao J, Zhao P, Lu J, Wang Y. Characterization of Neuraminidases from the Highly Pathogenic Avian H5N1 and 2009 Pandemic H1N1 Influenza A Viruses. PLoS One 2010; 5:e15825.

　　61. Wei B, Gao J, Huang XP, Ji G, Jin JP. Mutual rescues between two dominant-negative mutations in cardiac troponin I and cardiac troponin T. J Biol Chem. 2010; 285:27806-16. (影响因子5.328)

　　62. Zhou Y, Huang Q, Gao J, Lu J, Shen X, Fan C. A dumbbell probe-mediated rolling circle amplification strategy for highly sensitive microRNA detection. Nucleic Acids Res. 2010; 38(15)：e156.(影响因子7.479)

　　63. Huang X, Yu HS, Chen Z, Li JL, Hu ZM, Gao J*. A novel immunotherapy for superficial bladder cancer by the immobilization of streptavidintagged bioactive IL2 on the biotinylated mucosal surface of the bladder wall. Chin J Cancer 2010; 29:611-6.

　　64. Yin W, He Q, Hu Z, Chen Z, Qifeng M, Zhichun S, Zhihui Q, Xiaoxia N, Li J, Gao J*. A novel therapeutic vaccine of GM-CSF/TNFα surface-modified RM-1 cells against the orthotopic prostate cancer. Vaccine 2010; 28: 4946-4953. (影响因子3.766)

　　65. Zhang D, Li J, Costa M, Gao J*, Huang C*. JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70. Cancer Res 2010; 70:813-23. (影响因子8.234)

　　66. Hu Z, Tan W, Zhang L, Liang Z, Xu C, Su H, Lu J, Gao J*. A novel immunotherapy for superficial bladder cancer by intravesical immobilization of GM-CSF. J Cell Mol Med. 2010; 14:1836-44. (影响因子4.753)

　　67. Zhang D, Li J, Gao J*, Huang C*. c-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells. Toxicol Appl Pharmacol. 2009; 235(1)：18-24. (影响因子4.447)

　　68. Zhang D, Li J, Song L, Ouyang W, Gao J*, Huang C*. A JNK1/AP-1-dependent, COX-2 induction is implicated in 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation through regulating cell cycle progression. Mol Cancer Res. 2008; 6(1)：165-74. (影响因子4.288)

　　69. Ouyang W, Luo W, Zhang D, Jian J, Ma Q, Li J, Shi X, Chen J, Gao J, Huang C. PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation. Environ Health Perspect. 2008;116(1)：1-6. (影响因子5.8)

　　70. Gao J*, Huang S, Li M, Luo R, Wang X, Takashima A. GM-CSF- modified mouse B16.F10 melanoma whole cell vaccine. Vaccine 2006; 24: 5265-5268.(影响因子3.007)

　　71. Mizumoto N, Gao J, Matsushima H, Ogawa1 Y, Takashima A. Discovery of novel immunostimulants by dendritic cell-based functional screening. Blood 2005; 106:3082-3089.(影响因子10.12)

　　72. Z. Urban, J. Gao, FM. Pope, EC. Davis. Autosomal Dominant Cutis Laxa with severe lung disease: Synthesis and Matrix Deposition of Mutant Tropoelastin. J Invest Dermatol. 2005; 124: 1193-1199. (影响因子4.194)

　　73. Gao J, Takashima A. Cloning & Characterization of Actin, Tr 2 and Tr 4 genes of Trichophyton rubrum. J Clin Microbiol. 2004; 42: 3298-3299. (影响因子3.489)

　　74. Patterson CE, Gao J, Rooney AP, Davis EC. Genomic organization of mouse and human 65 kDa FK506-binding protein (FKBP65) genes and evolution of the FKBP multigene family. Geneomics 2002; 79: 881-889. (影响因子3.488)

　　75. Gao J, Waber L, Bennett MJ, Gibson KM, Cohen JC. Cloning and mutational analysis of human malonyl coenzyme A decarboxylase. J. Lipid Research 1999; 40:178-182. (影响因子3.893)

　　76. Vega GL, Gao J, Bersot TP, Mahley RW, Verstraaete R, Grundy SM, White A, Cohen JC. The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen- mediated stimulation of hepatic lipase activity. J. Lipid Research1998, 39: 1520-1524. (影响因子3.893)

　　77. Li S, Gao J, Satoh T, Friedman T, Edling A, Koch U, Choksi S, Han X, Korngold R, Huang Z. A computer screening approach to immunoglobulin superfamily structures and interactions: discovery of small non-peptidic CD4 inhibitors as novel immunotherapeutics. Proc Natl Acad Sci USA 1997; 94: 73-78. (影响因子9.737)

　　78. Gao J, Hwang J, Jin JP. Complete nucleotide sequence and structural organization of mouse h1-calponin gene. Biochem Biophys Res Commun1996; 218: 292-297. (影响因子2.406)

　　专利：

　　1. 高基民。链亲和素/粒细胞-巨噬细胞集落刺激因子融合蛋白。发明专利号ZL200410052536.4

　　2. 高基民。可溶性肿瘤坏死因子受体II-“脂联素”球部融合蛋白。发明专利号ZL200510100468.9

　　3. 高基民，胡志明，周明乾，林来新妹。链亲和素-白细胞介素2融合蛋白。发明专利申请号200710030119.3

　　4. 高基民，林来新妹，周明乾，胡志明。链亲和素-肿瘤坏死因子a融合蛋白。发明专利申请号200710030120.6

　　5. 高基民，林来新妹，苏华，张琳。绿色荧光蛋白/链亲和素融合蛋白。发明专利申请号2009100030119.3

　　6. 高基民，胡志明，林来新妹，苏华，张琳。链亲和素-白细胞介素15融合蛋白。发明专利申请号200910004309.3

　　7. 高基民，张政，许晓玲。链亲和素/白细胞介素7融合蛋白。发明专利申请号201010003372.1

　　8. 高基民，法萍萍，许晓玲。链亲和素/白细胞介素21融合蛋白。发明专利申请号201010003373.6

　　9. 高基民，尹卫华、许晓玲。GM-CSF/TNFα膜表面修饰的前列腺癌治疗性疫苗。发明专利号ZL201010195260.0

　　10. 高基民，邹立林，许晓玲。人心肌肌钙蛋白T/人心肌肌钙蛋白I融合蛋白。发明专利申请号201010228835.4

　　11. 高基民、张振、李金龙、许晓玲。链亲和素/sCD40L融合蛋白。发明专利申请号201010228717.3

　　12. 高基民，唐佳，许晓玲。一种新型的人白细胞介素-11。发明专利申请号201110026277.8

　　13. 高基民，吕建新、邹立林、郭芳芳、许晓玲。用于结核杆菌培养滤液蛋白10定量检测的标准品研制。发明专利号ZL201110060104.8

　　14. 高基民、董小岩、刘丹、陆月、吴小兵。肿瘤坏死因子受体Ⅱ-脂联素球部融合蛋白改构体快速筛选方法及应用。发明专利号ZL201110073658.1

　　专著：

　　1. 《临床分子生物学检验》(第3版)，2012，人民卫生出版社(ISNB 978-7-117-15269-3)(副主编)

　　2. 《分子诊断学实验指导》，2010，中国医药科技出版社(ISNB 978-7-5067-4534-5)(主编)

　　3. 《分子诊断学》，2010，中国医药科技出版社(ISNB 978-7-5-67-4537-6)(副主编)

　　4. 《分子生物学》，2010，高等教育出版社(ISNB 978-7-04-030529-6)(副主编)

　　科技奖励：

　　1. 细胞膜表面锚定修饰技术与新型肿瘤细胞疫苗。2013年浙江省科学技术奖“一等奖”(排名1/10)

　　2. 高基民杰出青年团队。浙江省自然科学基金“十一五”优秀项目。(排名1/10)

　　3. “新型肿瘤细胞生物治疗项目”创业计划书。2008年全国大学生“创业杯”铜奖 (指导老师)

　　4. 白介素II/LAK细胞制备和应用技术的综合研究。1994年广东省科技进步奖“二等奖”。(排名3/6)

　　5. 人乳头瘤病毒6，11，16 和18 型DNA检测、早期基因克隆及表达研究。1991年军队科技进步奖“二等奖”。(排名3/5)

　　附录3：高基民教授研究团队简况

　　本实验室(http://www.zjmolab.com/)研究方向：炎症相关疾病(肿瘤、自身免疫性疾病等)发生发展机制及其预防、诊治研究，如环境致癌物(如砷、镍、苯并芘等)的致癌机制，T淋巴细胞等免疫细胞的发育调控及其在肿瘤、器官移植和自身免疫性疾病中的作用，细胞膜表面锚定修饰的肿瘤细胞疫苗以及新型肿瘤坏死因子拮抗剂的研制、干细胞的转化医学研究等。

　　本实验室拥有强大的师资研究团队，部分导师简介：

　　黄传书教授(国家“千人”)

　　http://www.med.nyu.edu/biosketch/huangc05/publications

　　Dr. Katherine Siminovitich(加拿大皇家科学院院士、浙江省“千人”)

　　http://www.mshri.on.ca/simino/pages/kathy.htm

　　Dr. Andras Nagy (加拿大皇家科学院院士)

　　Dr. Andras Nagy — The Lunenfeld-Tanenbaum Research Institute

　　钟小平教授(浙江省“千人”)

　　http://cmb.duke.edu/research/faculty/xiaoping-zhong

　　喻启桂教授(浙江省“千人”)

　　http://micro.medicine.iu.edu/faculty/primary-faculty/andy-qigui-yu-m-d-ph-d/

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